Posted by Lilly from ? (160.129.27.22) on Tuesday, September 03, 2002 at 12:24PM :
In Reply to: from MD Consult posted by Lilly from ? (160.129.27.22) on Tuesday, September 03, 2002 at 12:10PM :
Half-life info on Lariam:
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CLINICAL PHARMACOLOGY:
Mefloquine is an antimalarial agent which acts as a blood schizonticide. Its exact mechanism of action is not known.
Pharmacokinetic studies of mefloquine in healthy male subjects showed that a significant lag time occurred after drug administration, & the terminal elimination half-life varied widely (13 to 24 days) with a mean of about three weeks. Mefloquine is a mixture of enantiomeric molecules whose rates of release, absorption, transport, action, degradation and elimination may differ. A valid pharmacokinetic model may not exist in such a case.
Additional studies in European subjects showed slightly greater concentrations of drug for longer periods of time. The absorption half-life was 0.36 to 2.0 hours, and the terminal elimination half-life was 15 to 33 days. The primary metabolite was identified and its concentrations were found to surpass the concentrations of mefloquine.
-- Lilly
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