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=> Anthrax and Cipro

Anthrax and Cipro
Posted by Tiglath (Guest) - Wednesday, October 15 2003, 12:19:35 (EDT)
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Apparently more people died being scared of the "Anthrax scare" than the 6 people who actually did die of the "Anthrax scare."

Is it really worth telling people that the Emperor is wearing no clothes?

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ANTHRAX AND CIPRO

As a result of the current Anthrax scare another fluorinated drug called CIPRO has received extensive media coverage and the name has become familiar to millions almost overnight. As soon as the first cases of anthrax resulting from suspicious mail became known, there were wide reports of a hectic run on this drug. Mass hysteria seems present as governments, pharmacies and individuals everywhere are stockpiling this drug. Pharmacies are reporting record sales, and on-line prescription services and Internet sites are found selling the drug at more than $7.00 per pill. People everywhere, hyped into believing their flu-like symptoms are caused by anthrax exposure and mis-informed by irresponsible media reports, are taking CIPRO, and worse yet - are giving it to their children. WHAT IS CIPRO? CIPRO is ciprofloxacin, a fluorinated quinolone, belonging to a class of fluorinated antibiotics which also include enoxacin, fleroxacin, temafloxacin, grepafloxacin, norfloxacin, sparfloxacin, tosufloxacin, lomefloxacin, ofloxacin, etc.. Ciprofloxacin has been in use since 1987 for a variety of other indications and is the most-widely used fluoroquinolone in humans and animals worldwide (4). In 2000 the FDA approved its use in treatment for inhalational anthrax under its "accelerated approval" regulations (5). It had actually taken the unusual step of urging Bayer - the sole manufacturer for all countries except India - to file for such approval, supposedly in order to protect the public from future terrorist attacks. The US Department of Defense had already ordered reserves of CIPRO during the 1991 Gulf War (6). ADVERSE EFFECTS: As mentioned in the info on BAYCOL, temafloxacin and grepafloxacin are two other fluoroquinolones now withdrawn from the market because they had caused severe liver and renal damage - and deaths, just like fluorinated drugs from other, different classifications (3). The same information also exists for CIPRO. Fatal liver failure associated with ciprofloxacin was reported in the Lancet in 1994 (7, 8 -> 150 more related refs). Ciprofloxacin has been implicated in several cases of acute renal failure and is the most established fluoroquinolone to cause such renal dysfunction (4, 9, 10, 11 -> 96 related refs). FLUORIDE The most common side-effects reported due to CIPRO (2-16%) are gastrointestinal in nature and equal those reported when children accidentally ingest "too much" fluoride from their toothpaste - such as nausea, diarrhea, vomiting, and abdominal pain. Why? Ciprofloxacin administration results in elevated serum fluoride levels (12). In a series of tests evaluating the safety of ciprofloxacin in children, serum fluoride levels increased after 12 hours in 79% of the children; on day 7 the 24-hour urinary fluoride excretion was higher in 88.9% of children observed (12). Just as in the case of Baycol and other fluorinated drugs, CIPRO can cause musculo-skeletal disorders such as rhabdomyolysis.



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